oral slope factor definition

 

 

 

 

From the BMDL10, adjusted for life stage From the BMDL10 From the BMDL10, adjusted for life stage From the oral slope factor, adjusted for life stage.No uncertainty factors were applied in this risk assessment, since an oral RfD was not determined. The carcinogenic effects observed in chronic II.B.1.1. Oral Slope Factor. Continuous lifetime exposure during adulthood Continuous lifetime exposure from birth. (a) LMS method (per mg/kg-day).In this case, the slope factors derived from both methods are virtually identical. Oral RfD (mg/kg-day).A cancer slope factor is currently available only for benzo[a]pyrene./ 365)). Definition (units). 95th Percentile PbB in Fetus (g/dL). Mean Ratio of Fetal to Maternal PbB. Although toxicity value point estimates are often used in this manner, it is important to note that the true definition, at least for an IRIS valueAn oral slope factor is an upper bound, approximating a 95 confidence limit, on the increased cancer risk from a lifetime oral exposure to an agent. (redirected from Slope Factor). Acronym. Definition.The EPA oral slope factors (potency factors) for carcinogen contaminants were applied to compute the cancer risk assessments (8). Similarly, an oral slope factor derived from administered dose data must be divided by a chemical-specific or default oral absorption factor such that the slope factor is adjusted to account for the absorbed dose. DEFINITIONS FOR CHAPTER 7 (continued).

Slope Factor.It is inappropriate to use the oral slope factor to evaluate the risks associated with dermal exposure to carcinogens such as benz(a)pyrene, which cause skin cancer through a direct action at the point of application. Following this definition, risk assessment is the process of estimating the probabili-ty of occurrence of an undesirable event and the magnitude of its consequences over a.Benzene (carcinogen) slope factors (SF) by inhalation and oral routes are the same, 2.9E-2 [mg/(kgd-1 benzene does not now Oral Slope Factor, Definition: An upper boun approximating a 95.

(IRIS ) Glossary System of Registries US EPA Confounder, Definition: A condition or variable that is both a risk factor for disease and. CANCER SLOPE FACTOR Thesaurus Definitions by Smart Define Dictionary. Top Voted Out Of 1 Entries Is oncology.Smart Define. (-0001). cancer slope factor thesaurus. CAS Number. Oral slope factor (1/mg/kg/d). Inhalation slope factor (1/mg/kg/d). Volatile Organic Compound (VOC)? ACETALDEHYDE. Oral slope factors for pcbs. Slope Factor (milligrams per kilogram-day)-1. Criteria for Use.However, an IRIS oral cancer slope factor is only available for benzo(a)pyrene. geometric mean ratio relative potency factor Registry of Toxic Effects of Chemical Substances structure activity relationship Subcommittee on Consequence Assessment and Protective Oral Slope Factor Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95 confidence limit Office of Research and Development National Center for Environmental Assessment. 4. Non-Cancer Reference Values: Definition.Oral Slope Factor (per mg/kg-day). The answer depends on the precise definition of toxicity and the specifics of the dose response relationship.A oral slope factor characterizes response to ingestion of a compound and is defined as the slope of a dose response curve in the low dose region. CSF is defined as Cancer Slope Factor frequently.This definition appears frequently and is found in the following Acronym Finder categories Cancer slope factor. HHRA Note 6 CAB Method 09282017 - dtsc.ca.gov.i Perchloroethylene Inhalation Cancer Potency Factor September, 2016 Perchloroethylene Inhalation Cancer Unit Risk Factor Technical Support Document for Cancer. D. Contact Us Cancer Assessment. Oral Slope Factor: Definition: An upper the extent to which the available data support the hypothesis that an agent causes cancer in humans. Search Search. Slope factor (mg/kg bw/d)-1. SCCP/1171/08. Scientific Committee on Consumer Safety (SCCS).TD-50s highlighted are those that are also associated with a potency exceeding the TTC limit. Chemical. EPA Oral Slope. Oral Slope Factor/GI Absorption Factor Slope Factorabsorbed. All gastrointestinal absorption data used in the conversions were obtained from literature searches.Therefore, this discussion focuses on the sources and definitions of the radionuclide toxicity values. The Medical Science Acronym /Abbreviation/Slang CSF means Cancer Slope Factor. by AcronymAndSlang.com.One of the definitions of CSF is "Cancer Slope Factor". 8 chronic oral reference dose (RfD) and slope factor (SFo) values.To the extent possible, definitions were taken 4 from the IRIS Glossary 2003 5 Acute Exposure: Exposure by the oral, dermal, or inhalation route for 24 hours or less. View Slope Factors from: Health Canada | US EPA. Chemical Name. CAS Number. Chemical Class. Oral slope factor (mg/kg-d)-1. Environmental Protection Agency. Issue Paper: Inorganic Arsenic Cancer Slope Factor.Currently, the Agencys Integrated Risk Information System (IRIS) carcinogenic risk from oral exposure to arsenic is based on southwestern Taiwanese skin cancer studies published in 1977 and 1968.Slope Factors for Slope Factors (SF) for Carcinogens Oral slope factor (1/mg/kg/d) Inhalation slope factor (1/mg/kg/d) Volatile Organic Compound Table Sources: I IRIS GLOSSARY FOR COMPLETION OF STANDARD TABLES TERM (TABLE DEFINITION ADDITIONAL LOCATION(S) IPCS. Definition : Equivalence : Acceptable Daily Intake.air Unit Risk. Excs de Risque Unitaire par ingestion. oral Slope Factor. Food and Agriculture Organisation. Guidelines for Drinking Water Quality. No oral slope factor or inhalation unit risk estimate were derived for naphthalene by the U.S. EPA because of the weakness of the evidence that naphthalene may be carcinogenic to humans (U.S. EPA 1998b). Оно может иметь другие определения. Пожалуйста, обратитесь к концу этого отрывка. Определение в английском языке: Cancer Slope Factor. Oral Carcinogen Group. Soil. Inhalation.For details on developing specific RfD, slope factor, or carcinogen class equivalent to USEPA categorization, see support document available by request to the Department. d Slope factor and carcinogen group of arsenic are those listed in IRIS under arsenic Parameter AF . AFi SAi . Definition (units) Adherence factor of soil to skin (mg/cm2-event). (Referred to as contact rate in RAGS, Part A).5.

2.3 TOXICITY ASSESSMENT. Oral reference doses and slope factors for dermal exposures. Our discussion of factors that can affect bioavailability will focus on oral bioavailability, however, some of the barriers for oral absorption are rel-evant to other routes.Definition The intercept of the slope associated with the distri Toxicity value for evaluating the probability of an individual developing cancer from exposure to contaminant levels over a lifetime. Definition. slope factor (SF, CPSF). Toxicity value for evaluating the probability of an individual developing cancer from exposure to contaminant levels over a lifetime. Rodent cancer bioassays indicate that substantial differences exist among PCB mixtures in terms of tumorigenic response, although no bioassay has been conducted with Aroclor 1268. The USEPA has used data from these studies to develop three sets of PCB cancer slope factors (CSFs) ranging from Some articles on slope factor: Negative P H - Definition and Measurement - P The calibration yields a value for the standard electrode potential, E0, and a slope factor, f, so that the Nernst equation in the form can be used to derive hydrogen ion oral cancer slope factor (mg/kg/day)-1. Chemical-specific b. WI water ingestion rate (L/day).Definition (units). Default Value. CTL RfDoral BW. cleanup target level (g/L) chronic oral reference dose (mg/kg/day) average body weight (kg). 3-10 Comparison of Slope Factors in Selected Slope Factor Models. 3-11 Effects of Nutritional Factors on Lead Uptake in Animals.Oral slope factor. Not available. Inhalation unit risk. The safety factor of slope is defined as the factor by which the original shear strength parameters be reduced to bring the slope to the point of failure.In fact this is the traditional definition of safety factor for slope stability. This definition has not yet been approved by a moderator.The slope factor is used to estimate an upper bound probability of an individual developing cancer as a result of a lifetime of exposure to a particular level of a potential carcinogen. SFo Slope Factor (Oral) SFa Slope Factor (Air) SFd Slope Factor (Dermal).By definition a slope factor is defined as: An upper bound, approximating a 95 confidence limit, on the increased cancer risk from a lifetime exposure to an agent. Topic: Oral Cancer Slope Factor. "Cancer Slope Factor (CSF): The upper-bound slope of the dose response curve for cancer effects derived from experimental data generally using the linearized multistage model." Table 7.2.6. Oral Cancer Slope Factors. CAS Number.Thus the duration of the exposure period (EP) and the averaging period (AP) for an chronic, subchronic or acute Average Daily Dose are variable factors depending upon the exposure being modelled, but the AP is set equal to EP by definition. SF stands for slope factors. This definition appears somewhat frequently.Chemical Name: CAS Number: Oral slope factor (1/mg/kg/d) Inhalation slope factor (1/mg/kg/d) Volatile Organic Compound (VOC)? Oral Slope Factor.SCREEN3 values are shown for comparison purposes. H.3 Definitions. It is convenient to define the following terms relating to sources with respect to the duration of the release. Density is also important factor in slope stability. However, its effect is more in mine waste dumps where it is a function of the manner of deposition, gradation, and loading history. A relatively small increase in density can increase the shear stre In this interpretation (which is implicit in the formal definition of uncertainty factors and their role in the RfD), the RfDs for different risk agents areIn this instance, the Toxicity is calculated from. the Cancer Slope Factor (Oral Slope Factor of Table 2). as follows: Toxicity (cancer) CSF 2 (L/day)/50 (kg). DEFINITIONS FOR CHAPTER 7 (continued). Slope Factor.It is inappropriate to use the oral slope factor to evaluate the risks associated with dermal exposure to carcinogens such as benz(a)pyrene, which cause skin cancer through a direct action at the point of application. Parameter/Definition (units) TR/target cancer risk (unitless) AT/averaging time (yr) SFo/ oral slope factor (mg/kg-d)-1 SFd/dermal slope factor (mg/kg-d)-1 EF/exposure frequency (d/yr). Arabic-English Spanish-French Spanish-Portuguese French-Spanish Portuguese-Spanish English definition English synonyms English collocations English usage Italian definition Spanishoral cancer slope factor. Discussion in Medical Terminology started by leitxu, Apr 24, 2008.

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